Antiosteoporotic activity of OST-6(Osteocare), a herbomineral preparation in calcium deficient ovariectomized rats.
نویسندگان
چکیده
The preventive effect of the herbal formulation OST-6 (Osteocare) on the progress of bone loss induced by ovariectomy and concurrent calcium deficiency was studied in rats. Ovariectomy (OVX) and calcium deficiency (CD) resulted in bone loss as evident from decreased femoral weight and density. Treatment with OST-6 at a dose of 250 mg/kg body wt twice a day orally for a period of 16 weeks significantly restored the femoral weight and density. The biomechanical strength of the tibia was decreased by OVX and CD and this was significantly suppressed by the administration of OST-6. Histologically decalcified bone sections revealed narrowed, and the disappearance of, trabeculae and widened medullary spaces. The total numbers of tartrate-resistant acid phosphates (TRAP) positive cells were increased significantly in OVX animals. Treatment with OST-6 significantly inhibited these histopathological changes and strongly suggested that OST-6 was effective in preventing the progress of bone loss induced by ovariectomy and concurrent calcium deficiency.
منابع مشابه
Prevention of bone loss in calcium deficient ovariectonized rats by OST-6, a herbal preparation.
OST-6, a herbomineral preparation, was studied for its inhibitory effects on the progress of bone loss induced by ovariectomy (OVX) and concurrent calcium deficiency in rats. Calcium deficient ovariectomized rats were administered with OST-6 at 250 mg/kg b. w. twice a day orally for 16 weeks. Compared with sham operated animals, OVX animals showed an increase in serum ALP, urinary excretion of ...
متن کاملWater Soluble Components of ‘Osteocare’ Promote Cell Proliferation, Differentiation, and Matrix Mineralization in Human Osteoblast-Like SaOS-2 Cells
Osteocare, a herbal formulation, has been found to be very effective in bone mineralization and support of the microstructure of bone tissue. The water-soluble components of Osteocare (WSCO) induced osteogenic activity in human osteoblast-like SaOS-2 cells. The addition of WSCO (100 μg/ml) to SaOS-2 cells was effective in increasing the cell proliferation by 41.49% and DNA content by 1.9-fold. ...
متن کاملAnti-osteoporotic activity of ethanol extract of Terminalia arjuna (Roxb.) Wight & Arn. on ovariectomized rats
Terminalia arjuna (Roxb.) Wight & Arn., a widely growing plant in India, possesses different medicinal properties and its bark is well known for their bone remineralization properties. The objective of present study was to evaluate antiosteoporotic activity of ethanol extract of T. arjuna (EET) on ovariectomized female Sprague Dawley model rats, divided into six groups. Sham operated control gr...
متن کاملInhibitory effects of morinda officinalis extract on bone loss in ovariectomized rats.
The present study was undertaken to investigate the protective effects of ethanol extract from the root of Morinda Officinalis (RMO) on ovariectomy-induced bone loss. Administration of RMO extract increased trabecular bone mineral content and bone mineral density of tibia, improved the levels of phosphorus (P), calcium (Ca) and OPG, decreased the levels of DPD/Cr, TRAP, ACTH and corticosterone,...
متن کاملHistological Changes in the Fracture Callus Following the Administration of Water Extract of Piper Sarmentosum (Daun Kadok) in Estrogen-Deficient Rats
Background: The fracture healing is impaired in osteoporosis. Piper sarmentosum is a plant, which contains potent antioxidant, naringenin that may enhance fracture healing. The present histological study aimed to determine the effects of water extract of Piper sarmentosum on the late phase of fracture healing in estrogen-deficient rats. Methods: Twenty four female Sprague-Dawley rats (2...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Phytotherapy research : PTR
دوره 18 1 شماره
صفحات -
تاریخ انتشار 2004